CHINESE老熟妇老女人HD,色欲蜜桃AV无码中文字幕,成人免费ā片在线观看,japan高清日本乱xxxxx

當(dāng)前位置:首頁  >  技術(shù)文章  >  RGDSP功能化肽水凝膠,促進(jìn)人羊膜間充質(zhì)干細(xì)胞創(chuàng)面愈合

RGDSP功能化肽水凝膠,促進(jìn)人羊膜間充質(zhì)干細(xì)胞創(chuàng)面愈合

更新時(shí)間:2025-01-27  |  點(diǎn)擊率:164

202410月,貴州省細(xì)胞工程重點(diǎn)實(shí)驗(yàn)室,遵義醫(yī)學(xué)院附屬醫(yī)院,遵義醫(yī)科大學(xué)附屬醫(yī)院臨床干細(xì)胞研究所,湖北醫(yī)科大學(xué)附屬太和醫(yī)院創(chuàng)面修復(fù)與皮膚外科 (Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, China,The Clinical Stem Cell Research Institute, Affiliated Hospital of Zunyi Medical University, Zunyi, China,Department of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, China) Wei Wei老師研究團(tuán)隊(duì)在《Frontiers in Bioengineering and Biotechnology》上發(fā)表論文:

RGDSP-functionalized peptide hydrogel stimulates growth factor secretion via integrin αv/PI3K/AKT axis for improved wound healing by human amniotic mesenchymal stem cells"

 

RGDSP功能化肽水凝膠通過整合素αv/PI3K/AKT軸刺激生長因子分泌,促進(jìn)人羊膜間充質(zhì)干細(xì)胞創(chuàng)面愈合"

 

Abstract

The wound healing process involves communication among growth factors, cytokines, signaling pathways, and cells in the extracellular matrix, with growth factors acting as key regulators. Although stem cells can promote wound healing by secreting diverse growth factors, their therapeutic potential is hindered by poor survival and engraftment. Mimicking the stem cell-matrix interactions can improve stem cell survival, regulate their fate, and even enhance their paracrine effects. This study investigated the use of composite RGDmix hydrogel, which can support the survival and proliferation of human amniotic mesenchymal stem cells (hAMSCs), and effectively increase the expression of various growth factors, thereby promoting wound re-epithelialization, angiogenesis, and epidermal maturation. At last, the specific role of integrin αv and PI3K/AKT signaling pathways in the secretion of growth factors were examined by silencing them in vitro and in vivo. Results suggested that the RGDmix hydrogel improved the secretion of growth factors by hAMSCs through the RGDSP/integrin αv/PI3K/AKT axis, thereby enhancing the therapeutic effect in wound healing.


摘要:

傷口愈合過程涉及生長因子、細(xì)胞因子、信號(hào)通路和細(xì)胞外基質(zhì)細(xì)胞之間的交流,其中生長因子是關(guān)鍵的調(diào)節(jié)因子。雖然干細(xì)胞可以通過分泌多種生長因子促進(jìn)傷口愈合,但其治療潛力受到生存和植入性差的阻礙。模擬干細(xì)胞與基質(zhì)的相互作用可以提高干細(xì)胞的存活率,調(diào)節(jié)其命運(yùn),甚至增強(qiáng)其旁分泌作用。本研究研究了復(fù)合RGDmix水凝膠能夠支持人羊膜間充質(zhì)干細(xì)胞(hAMSCs)的存活和增殖,并有效增加各種生長因子的表達(dá),從而促進(jìn)創(chuàng)面再上皮化、血管生成和表皮成熟。最后,通過體外和體內(nèi)實(shí)驗(yàn),研究整合素αvPI3K/AKT信號(hào)通路在生長因子分泌中的具體作用。結(jié)果表明,RGDmix水凝膠通過RGDSP/integrin αv/PI3K/AKT軸促進(jìn)hAMSCs分泌生長因子,從而增強(qiáng)傷口愈合的治療效果。

 

該論文中,hAMSCs的體外培養(yǎng)是使用Ausbian特級(jí)胎牛血清完成的。


好涨嗯太深了嗯啊用力别停| 国产人妻丰满熟妇嗷嗷叫| 欧美无人区码suv| 小少爷撅着屁股挨c双龙| 肉妇春潮干柴烈火| 欧美老妇人与黑人做爰| 久人人爽人人爽人人片AV| 扒开她稚嫩的小屁股坐下去| 人人澡人人澡人人看添av| 亚洲人妻| 人人妻人人澡人人爽国产 | 一性一交一伦一片a片庆| 弥留之国的爱丽丝第一季| 国产xxx69麻豆国语对白| 美国zoom动物| 国产精品99久久久久久擦边| 亚洲 都市 校园 激情 另类| 男男惩罚羞耻双腿分打屁股小作文| 我和小堂妺的第一次| 在闺房里被强高h| 少妇饥渴偷公乱400章深夜书屋| 亚无码乱人伦一区二区| 成人情趣玩具| 成人性生交大片免费看京东小视频| 歪歪漫画入口弹窗页面打开| 一区二区三区精华液| 掉入男人世界的女人阅读| 女局长白白嫩嫩大屁股| 扒开双腿猛进入JK校花免费网站| 秋霞在线看片无码免费| 久久av| 女人被添荫蒂舒服极了| 漂亮人妻洗澡被公强| 小雪被老汉各种姿势玩| 国产福利精品一区二区| 国色天香精品一卡2卡3卡| 被黑人玩得站不起来| 奇米777四色影视在线看| 国产无套内射普通话对白| 成人av无码一区二区三区| 韩国三级hd中文字幕|